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Desglymidodrine

from midodrine

What it isThe active metabolite of midodrine, an alpha-1 agonist; orthostatic hypotension.

Why it mattersIt raises standing blood pressure without crossing into the CNS.

What it changesSupine hypertension — the last dose must be hours before lying down. Renally cleared.

NO BOXED WARNINGS

Principal riskSupine hypertension

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Desglymidodrine ballicule

Desglymidodrine ballicule: receptor binding, kinetics and half-life diagram

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