BBB: limited entry
- CNS penetration is present but restricted
- Peripheral exposure exceeds brain exposure
- Transporters/ionization may limit entry
- CNS effects can still occur at higher exposure
- Useful middle category between crosses/excluded
Interaction at a glance
- CNS penetration is present but restricted
Mechanism
- CNS penetration is present but restricted
Mechanism / modifiers
- Transporters/ionization may limit entry
- Useful middle category between crosses/excluded
Magnitude / time course
- Peripheral exposure exceeds brain exposure
- CNS effects can still occur at higher exposure
Self-check
- What can restrict CNS entry despite some BBB penetration?
Transporters or ionization. - Can limited-BBB-entry drugs cause CNS effects at higher exposure?
Yes.
Drugs in this interaction (164)
All interaction examples · Open BBB: limited entry in the interactive console ↗