BBB: limited entry
- CNS penetration is present but restricted
- Peripheral exposure exceeds brain exposure
- Transporters/ionization may limit entry
- CNS effects can still occur at higher exposure
- Useful middle category between crosses/excluded
Interaction at a glance
- CNS penetration is present but restricted
Mechanism
- CNS penetration is present but restricted
Mechanism / modifiers
- Transporters/ionization may limit entry
- Useful middle category between crosses/excluded
Magnitude / time course
- Peripheral exposure exceeds brain exposure
- CNS effects can still occur at higher exposure
Self-check
- What does the tag “BBB: limited entry” indicate?
CNS penetration occurs, but is restricted.
Drugs in this interaction (164)
All interaction examples · Open the interactive console ↗
