Bictegravir
in BIKTARVY
What it isHIV integrase strand transfer inhibitor; part of a single-tablet regimen.
Why this oneHigh barrier to resistance in a once-daily single tablet with no booster, which is why it is a preferred first-line regimen.
What limits itPolyvalent cations block absorption — separate antacids and supplements. It raises creatinine by inhibiting tubular secretion, without changing GFR.
FDA-approved for
- HIV infection (2018)
⚠ BOXED WARNING
- Severe acute exacerbation of hepatitis B on discontinuation
Classes and tags
Clinical profile
Mechanism of action: Bictegravir ballicule
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