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Sarcosine

N-methylglycine

What it isN-methylglycine, a glycine transporter type 1 inhibitor and NMDA co-agonist.

Why this oneIt raises synaptic glycine, which is the same target the failed GlyT1 drugs pursued.

What limits itHuman evidence is limited to small adjunct trials in schizophrenia. Sold as an unregulated supplement.

NO BOXED WARNINGS

Principal riskHuman evidence is limited to small adjunct trials in schizophrenia

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Sarcosine ballicule

Sarcosine ballicule: receptor binding, kinetics and half-life diagram

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