Sarcosine
N-methylglycine
What it isN-methylglycine, a glycine transporter type 1 inhibitor and NMDA co-agonist.
Why this oneIt raises synaptic glycine, which is the same target the failed GlyT1 drugs pursued.
What limits itHuman evidence is limited to small adjunct trials in schizophrenia. Sold as an unregulated supplement.
NO BOXED WARNINGS
Principal riskHuman evidence is limited to small adjunct trials in schizophrenia
Classes and tags
Clinical profile
Defining liabilityLimited long-term clinical safety and mood-activation uncertainty
Available strengths
- powder 2 g/scoop (trial dose)
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Self-check
- Sarcosine: What synaptic transmitter does it raise?
Glycine. - Sarcosine: How extensive is the human schizophrenia evidence?
Small adjunct trials only.