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Choline

What it isEssential nutrient and the precursor from which acetylcholine is synthesized.

Why this oneSupply can limit acetylcholine synthesis, which is the rationale behind choline-donor supplements.

What limits itSupplement evidence for cognition is weak; the rate-limiting step is usually the transporter, not substrate supply.

NO BOXED WARNINGS

Principal riskEndogenous or dietary; no boxed warning applies

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Active metabolites

Mechanism of action: Choline ballicule

Choline ballicule: receptor binding, kinetics and half-life diagram

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