Clobetasol
TEMOVATE
What it isSuperpotent topical glucocorticoid-receptor agonist; psoriasis, lichen planus, and severe eczema.
Why this oneIt is standard first-line treatment for vulvar lichen sclerosus, despite usual caution with superpotent steroids on thin skin.
What limits itSkin atrophy and striae follow overuse; large areas or occlusion can suppress the adrenal axis, so keep courses brief and localized.
FDA-approved for
- corticosteroid-responsive dermatoses (superpotent)
Off-label
- oral lichen planus
- vulvar lichen sclerosus
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Corticosteroid-responsive dermatoses | Adult | Apply thin layer twice daily (BID) | 50 g/week; 2 consecutive weeks |
Renal Undefined
Hepatic Undefined
Instructions
- Apply a thin layer to affected skin twice daily and rub in gently and completely
- Limit treatment to 2 consecutive weeks; do not exceed 50 g per week (super-high potency)
- Do not use with occlusive dressings
- Discontinue when control is achieved; reassess diagnosis if no improvement within 2 weeks
Cautions
- HPA-axis suppression / Cushing's syndrome with prolonged use (reported in infants and adults)
- Local reactions: skin atrophy, striae, telangiectasia, folliculitis
- Allergic contact dermatitis
- Secondary skin infection
Adverse reactions
- Burning sensation
- Irritation
- Itching
- Stinging
- Cracking
- Erythema
- Skin atrophy
- Telangiectasia
Pregnancy Teratogenic in animals when given subcutaneously (cleft palate, skeletal defects); use during pregnancy only if potential benefit justifies risk.
Lactation Undefined
NO BOXED WARNINGS
Principal riskSkin atrophy and striae; axis suppression over large areas
Cost, est. cash$10–$300/month
Generic entry1994
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityLocal tissue effects and irritation; systemic corticosteroid toxicity is uncommon at usual exposure.
Mechanism of action: Clobetasol ballicule
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Memory aids: mascots and interaction avatars
