Methylcobalamin
VITAMIN B12
What it isThe methyl coenzyme form of vitamin B12, cofactor for methionine synthase.
Why it mattersIt is the form required to remethylate homocysteine, which is why B12 deficiency raises homocysteine.
What it changesNo proven advantage over cyanocobalamin for ordinary repletion, despite marketing to the contrary.
FDA-approved for
- vitamin B12 deficiency
Off-label
- vitamin B12 supplementation
NO BOXED WARNINGS
Principal riskNo proven advantage over cyanocobalamin for correcting deficiency; the difference is largely mar
Classes and tags
Clinical profile
Mechanism of action: Methylcobalamin ballicule
