Ketotifen
ZADITOR
What it isH1 antagonist with mast-cell stabilization; allergic conjunctivitis.
Why this oneIts inexpensive over-the-counter eye drops combine immediate antihistamine relief with prevention of further mediator release.
What limits itLocal burning or irritation can stop use; oral ketotifen, used outside the US, is sedating.
FDA-approved for
- allergic conjunctivitis (1999)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Eye itch due to allergy | adults & children ≥3 yr | 1 drop in affected eye(s) BID (q8-12h) | no more than twice per day |
Renal Undefined
Hepatic Undefined
Instructions
- If using other ophthalmic products, wait at least 5 minutes between each product
- Children under 3 yr: consult a doctor
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskLocal irritation
Cost, est. cash$10–$30/month
Generic entry2012
Classes and tags
Clinical profile
Legacy pregnancy categoryNot assigned — OTC/monograph
Defining liabilityLocal irritation, sensitization or administration-site injury; negligible systemic toxicity at usual use.
Mechanism of action: Ketotifen ballicule
