Ketoprofen
ORUVAIL
What it isNon-selective NSAID; arthritis and pain.
Why this onePotent analgesia, and a topical form gives local effect with low systemic exposure.
What limits itStandard NSAID GI, renal and cardiovascular risk. Photosensitivity with the topical form; it raises serum lithium.
FDA-approved for
- pain (1986)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Rheumatoid arthritis / osteoarthritis | adult | 75 mg TID or 50 mg QID | 300 mg/day | |
| Mild-to-moderate pain and dysmenorrhea | adult | 25-50 mg q6-8h PRN | doses >75 mg give no added analgesia; ≤300 mg/day |
Renal Mild impairment: max 150 mg/day. Severe (GFR <25 mL/min/1.73m² or ESRD): max 100 mg/day
Hepatic Impaired liver function with albumin <3.5 g/dL: max initial 100 mg/day
Instructions
- Use lowest effective dose for shortest duration
- May take with antacids, food, or milk to reduce GI effects
- Reduce initial dosage in patients over 75 yr
Contraindications
- Asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Coronary artery bypass graft (CABG) surgery
Cautions
- Cardiovascular thrombotic events
- GI bleeding, ulceration, perforation
- Hepatotoxicity
- Hypertension, heart failure/edema
- Renal toxicity
- Anaphylactoid reactions
- Serious skin reactions
Adverse reactions
- Dyspepsia and other GI symptoms (nausea, abdominal pain, diarrhea, constipation, flatulence)
- Peptic ulcer/GI bleeding
- Headache
- Fluid retention
Pregnancy Avoid at ~30 weeks gestation and later (premature ductus arteriosus closure); limit use 20-30 weeks (oligohydramnios/neonatal renal impairment)
Lactation Undefined
⚠ BOXED WARNINGS
- Cardiovascular thrombotic events
- Gastrointestinal bleeding, ulceration and perforation
Cost, est. cash$10–$500/month
Generic entry1992
Classes and tags
Clinical profile
Legacy pregnancy categoryMultiple / indication-, trimester- or formulation-dependent
Defining liabilityGI bleeding, kidney injury, hypertension and fluid retention; many agents increase lithium concentrations.
Mechanism of action: Ketoprofen ballicule
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Memory aids: mascots and interaction avatars
“The N said... NSAID”
