N-acetylcysteine (NAC)
NAC
What it isGlutathione precursor and mucolytic; acetaminophen overdose and thick respiratory secretions.
Why this oneIt restores hepatic glutathione and is fully protective when started within eight hours of acetaminophen overdose.
What limits itIV infusion can cause rate-related anaphylactoid reactions rather than true allergy. The oral form smells of sulfur.
FDA-approved for
- acetaminophen overdose (~1985)
- mucolytic (~1963)
Off-label
- trichotillomania
- contrast nephropathy prophylaxis
NO BOXED WARNINGS
Principal riskAnaphylactoid infusion reactions, usually rate-related
Classes and tags
Clinical profile
Mechanism of action: N-acetylcysteine (NAC) ballicule
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