Agmatine
endogenous
What it isDecarboxylated arginine acting at imidazoline receptors and as a negative modulator at the NMDA polyamine site.
Why this oneA putative neuromodulator that sits at the junction of the nitric oxide and glutamate systems.
What limits itHuman evidence for the supplement is limited, and oral bioavailability is poor.
Used for
- dietary supplement (no approved indication)
- neuropathic pain (limited human evidence)
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies
Classes and tags
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Self-check
- How strong is human evidence for agmatine supplementation?
Limited. - How good is agmatine’s oral bioavailability?
Poor.