Oxaprozin
DAYPRO
What it isLong-acting COX-1 and COX-2 inhibitor; osteoarthritis and rheumatoid arthritis.
Why this oneIts unusually long persistence permits once-daily use but offers little flexibility when toxicity develops.
What limits it⚑ GI bleeding, kidney injury, cardiovascular events, and lithium elevation remain the main hazards.
FDA-approved for
- arthritis (1992)
FDA label
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| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Osteoarthritis | Adults | 1200 mg QD | 1200 mg QD | |
| Rheumatoid arthritis | Adults | 1200 mg QD | 1200 mg QD | |
| Juvenile rheumatoid arthritis | Peds 6-16 yr, by weight | 600 mg QD (22-31 kg); 900 mg QD (32-54 kg); 1200 mg QD (≥55 kg) | same | 1200 mg QD |
Renal Avoid in advanced renal disease unless benefits outweigh risk; monitor renal function in renal/hepatic impairment
Hepatic Undefined (monitor for hepatotoxicity; no specific dose adjustment stated)
Instructions
- Use lowest effective dose for shortest duration consistent with treatment goals
Contraindications
- History of asthma, urticaria, or allergic-type reaction after aspirin or other NSAIDs
- Setting of CABG surgery
Cautions
- Cardiovascular thrombotic events
- GI bleeding/ulceration/perforation
- Hepatotoxicity
- Hypertension
- Heart failure and edema
- Renal toxicity and hyperkalemia
- Anaphylactic reactions
- Serious skin reactions
- Hematologic toxicity
Adverse reactions
- Constipation
- Diarrhea
- Dyspepsia
- Nausea
- Rash
Pregnancy Avoid at ~30 wks gestation or later (premature closure of fetal ductus arteriosus); limit use 20-30 wks (oligohydramnios/neonatal renal impairment)
Lactation Undefined
⚠ BOXED WARNINGS
- Cardiovascular thrombotic events
- Gastrointestinal bleeding, ulceration and perforation
Cost, est. cash$10–$300/month
Generic entry2001
Classes and tags
Clinical profile
Legacy pregnancy categoryMultiple / indication-, trimester- or formulation-dependent
Defining liabilityGI bleeding, kidney injury, hypertension and fluid retention; many agents increase lithium concentrations.
Mechanism of action: Oxaprozin ballicule
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