Tedizolid
SIVEXTRO
Pronunciation: te-DIZ-oe-lid
What it isOxazolidinone inhibiting the 50S subunit; acute bacterial skin infection.
Why this oneOnce daily for six days rather than twice daily for ten, with less myelosuppression than linezolid.
What limits itA weaker MAO inhibitor than linezolid but the caution remains. No Gram-negative cover.
Pearls
- Same 200 mg once-daily dose IV or oral.
Tedizolid prescription history
Animated chart of estimated U.S. prescriptions per year, Antibacterials (systemic) (1938–2026). Tedizolid enters in 2014 (estimated).
Principal riskIt is a weaker MAO inhibitor than linezolid but the caution remains
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityAllergy, gastrointestinal effects and agent-specific renal, hepatic, hematologic or interaction risks.
FDA label
Read the full label on DailyMed ↗
NO BOXED WARNINGS
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Acute bacterial skin & skin structure infection (ABSSSI) | Adults | 200 mg QD | 200 mg QD | 200 mg QD |
| ABSSSI | Peds ≥35 kg (oral) | 200 mg QD | 200 mg QD | |
| ABSSSI (IV) | Peds ≥26 wk gestational age & ≥1 kg | 1–<2 kg 3 mg/kg BID; 2–<3 kg 6 mg BID; 3–<6 kg 12 mg BID; 6–<10 kg 20 mg BID; 10–<14 kg 30 mg BID; 14–<20 kg 40 mg BID; 20–<35 kg 60 mg BID; ≥35 kg 200 mg QD | Same weight-band dose, 1-hr infusion, 6 days |
Renal Undefined
Hepatic Undefined
Instructions
- 6-day course, oral (with or without food) or IV infusion over 1 hour
- No dose adjustment when switching IV to oral (adults; tablets only for peds ≥35 kg)
- Do not give Sivextro tablets to pediatric patients <35 kg
Available strengths
- tab 200 mg
- inj 200 mg
Cautions
- Serotonin syndrome reported with concomitant serotonergic agents — monitor; consider discontinuing
- Not adequately studied in neutropenia (<1000 cells/mm3) — consider alternatives
- C. difficile-associated diarrhea
Adverse reactions
- Adults: nausea, headache, diarrhea, infusion/injection-site reactions, vomiting, dizziness
- Peds: phlebitis, increased hepatic transaminases, injection reactions, vomiting
Pregnancy May cause fetal harm (animal data); human data insufficient — advise of potential risk
Lactation No human data; present in rat milk — weigh benefits vs need
Cost
| Strength | #/mo | generic $ | brand $ | CostPlus | |
|---|---|---|---|---|---|
| 200 mg | tab | 30 qd | — | $14,273.71/mo | not offered |
| 200 mg | inj | per unit | — | not offered |
Generic entry2030 est.
Serotonin and MAOI
Provisional washout figures
Elevating mechanismMAO-A inhibitor
Non-elevating actionNone recorded
Exposure dependenceUncertain/exposure dependent
Washout AFTER an MAOI1 days
Evidence confidenceModerate
InterpretationOxazolidinone with weaker/less certain clinically relevant MAO-A inhibition than linezolid.
Open Tedizolid in the interactive console ↗
Self-check
- What is tedizolid’s dosing schedule for its supplied skin-infection role?
Once daily for six days. - Does tedizolid provide Gram-negative coverage?
No.