BBB: largely crosses

Interaction at a glance

• Substantial CNS penetration

Mechanism

• Substantial CNS penetration
• Not necessarily equal to free plasma concentration

Magnitude / time course

• Brain exposure is clinically important
• Some efflux/metabolism may still limit levels

Clinical consequence

• Central efficacy/toxicity should be expected

Self-check

• Key risk with BBB: largely crosses?
  Central efficacy/toxicity should be expected.
• Does substantial CNS penetration imply brain levels equal free plasma levels?
  Not necessarily.

Drugs in this interaction (179)

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