BBB: largely crosses
- Substantial CNS penetration
- Brain exposure is clinically important
- Some efflux/metabolism may still limit levels
- Central efficacy/toxicity should be expected
- Not necessarily equal to free plasma concentration
Interaction at a glance
- Substantial CNS penetration
Mechanism
- Substantial CNS penetration
- Not necessarily equal to free plasma concentration
Magnitude / time course
- Brain exposure is clinically important
- Some efflux/metabolism may still limit levels
Clinical consequence
- Central efficacy/toxicity should be expected
Self-check
- What is the main clinical risk of BBB: largely crosses?
Central efficacy/toxicity should be expected.
Drugs in this interaction (179)
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