Berberine
botanical
What it isPlant alkaloid with AMPK activation and modest glucose and lipid lowering.
Why this oneIts glycemic effect approaches that of low-dose metformin in trials, which is unusual for a supplement.
What limits itIt is a moderate CYP3A4 and CYP2D6 inhibitor, so interactions are real. Product content is unregulated.
FDA-approved for
- herbal supplement (glycemic/lipid)
Off-label
- type 2 diabetes
- dyslipidemia
NO BOXED WARNINGS
Principal riskModerate CYP3A4 and CYP2D6 inhibition; unregulated content
Classes and tags
Clinical profile
Mechanism of action: Berberine ballicule
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