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Loratadine

CLARITIN

What it isSecond-generation H1 antagonist; allergic rhinitis and urticaria.

Why this oneIt causes less drowsiness than cetirizine, but fexofenadine is generally the least sedating oral option.

What limits itIts low sedation comes with weaker urticaria control than cetirizine; inadequate control often prompts a switch.

FDA-approved for

FDA label

FDA dosingPopulationStartTargetMax
Allergy relief (OTC antihistamine)Adults & children ≥6 yr10 mg (1 tablet) QD1 tablet/24 hr

Renal Undefined

Hepatic Undefined

Instructions

Pregnancy Undefined

Lactation Undefined

NO BOXED WARNINGS

Principal riskWeaker than cetirizine in urticaria

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Loratadine ballicule

Loratadine ballicule: receptor binding, kinetics and half-life diagram

Open Loratadine in the interactive console ↗

Memory aids: mascots and interaction avatars

Loratadine CLARITIN mascot mnemonic cartoon
“Low rat dines with Clarity”

Open Loratadine in the interactive console ↗