EXP3179
losartan metabolite
What it isAldehyde intermediate in losartan metabolism, with no AT1 activity but PPAR-gamma and COX-2 effects.
Why it mattersMay account for anti-inflammatory effects of losartan that AT1 blockade does not explain.
What it changesLosartan is not a pure prodrug: three species with different actions circulate together.
Used for
- intermediate metabolite of losartan
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Active metabolites
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Self-check
- Does EXP3179 block AT1 receptors?
No. - Which nuclear receptor activity is described for EXP3179?
PPAR-gamma activity.