EXP3179
losartan metabolite
What it isThe aldehyde intermediate in losartan metabolism, with no AT1 activity but PPAR-gamma and COX-2 effects.
Why it mattersIt may account for anti-inflammatory effects of losartan that AT1 blockade does not explain.
What it changesIt is a reminder that losartan is not a pure prodrug — three species with different actions circulate at once.
FDA-approved for
- intermediate metabolite of losartan
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Clinical profile
Active metabolites
Mechanism of action: EXP3179 ballicule
