EXP3174 (E-3174)
losartan metabolite
What it isCarboxylic acid metabolite of losartan, a more potent and insurmountable AT1 antagonist.
Why it mattersProvides most of losartan’s blood-pressure effect and its longer duration.
What it changesCYP2C9 poor metabolizers form less, explaining losartan’s poorer performance in this group; the parent alone is weak.
Used for
- hypertension (active metabolite of losartan)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug
Classes and tags
Open EXP3174 (E-3174) in the interactive console ↗
Self-check
- How does EXP3174’s AT1 antagonism compare with losartan’s?
More potent and insurmountable. - Which poor-metabolizer phenotype reduces EXP3174 formation?
CYP2C9.