Mechanism of action: Hypericin ballicule
Visual mnemonic: Hypericin mascot
“Hyper rice”
says St John’s wort
What it isSt John’s wort pigment and a photosensitiser.
Why this oneThe constituent behind the phototoxicity of the herb.
What limits itAlso the compound most often standardized on the label, though hyperforin drives the interactions.
Molecular structure: Hypericin
Used for
- St John's wort constituent (not approved)
- St John's wort constituent studied for depression and as a photosensitizer
Principal riskPhotosensitivity
Classes and tags
Clinical profile
Therapeutic safety burden3 / 4
Direct muscarinic antagonism0 / 4
Defining liabilityDose- and light-dependent phototoxicity
Open Hypericin in the interactive console ↗
Self-check
- Which St John’s wort adverse effect is linked to hypericin?
Phototoxicity. - Which constituent drives interactions despite hypericin often appearing on labels?
Hyperforin.