Nav1.5 blocker

Nav1.5 cardiac sodium channel blocker

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Blocks the cardiac Nav1.5 channel → slowed conduction, QRS widening
Distinct from the neuronal sodium lanes — spike-suppressing, late-current and peripheral blockers are separate mechanisms

Drugs with this mechanism (90)

Ajmaline Amiodarone Amitriptyline Amoxapine Bupropion hydrobromide ER Aprindine Bupropion Carbamazepine Carbamazepine ER capsules Chloroquine Chlorpromazine Chlorpromazine injection Cibenzoline Citalopram Clomipramine Cocaine Cyclobenzaprine Desipramine Desmethyl clomipramine Dimenhydrinate Diphenhydramine Diphenhydramine injection Disopyramide Doxepin Venlafaxine XR Encainide Carbamazepine ER (Equetro) Eslicarbazepine Ethacizine Flecainide Bupropion XL 450 mg Haloperidol Haloperidol decanoate LAI Haloperidol injection Hydroquinidine Hydroxybupropion Hydroxy nefazodone Imipramine Lacosamide Lacosamide ER Lamotrigine XR Lamotrigine Lidocaine Lidocaine injection Loperamide Maprotiline Methadone Mexiletine Mirtazapine Moricizine Nefazodone Nordoxepin Nortriptyline Oxcarbazepine Oxcarbazepine XR Phenytoin Pilsicainide Procainamide Propafenone Propranolol Propranolol ER Protriptyline Topiramate ER (sprinkle) Quetiapine Quinidine Ranolazine Rufinamide Quetiapine XR Doxepin low-dose (insomnia) Carbamazepine XR Thioridazine Tocainide Topiramate Topiramate ER Tramadol Trazodone Trimipramine Tramadol ER Valproic acid Divalproex DR Divalproex ER Valproate sodium IV Divalproex sprinkle Venlafaxine Bupropion SR Bupropion XL Ziprasidone Ziprasidone IM Zonisamide Bupropion SR (smoking cessation)

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