Bupropion SR (smoking cessation)
ZYBAN
Pronunciation: byoo-PROE-pee-on
“Boop ropin’ Well booty”
Strong CYP2D6 inHibitor
Skinny → weight loss possible
What it isNorepinephrine-dopamine reuptake inhibitor and neuronal nicotinic antagonist; smoking cessation.
Why this oneUnder ZYBAN, the smoking-cessation indication lives here, not on Wellbutrin; same 150 mg SR tablet, but this label is for quitting.
What limits itDose-related seizures rule it out in seizure or eating disorders; insomnia, hypertension, and the suicidality warning also matter.
FDA-approved for
- smoking cessation (1997)
⚠ BOXED WARNING
- Suicidal thoughts and behaviors in patients under 25
Classes and tags
Clinical profile
Legacy pregnancy categoryC
Defining liabilityDose-related seizures and delayed cardiotoxicity are prominent in overdose, especially with extended-release products.
Available strengths
- ER tab 150 mg (SR)
Active metabolites
Open Bupropion SR (smoking cessation) in the interactive console ↗
Memory aids: interaction avatars
Open Bupropion SR (smoking cessation) in the interactive console ↗
Self-check
- Which tablet formulation is used for Zyban?
150 mg SR. - Which preexisting disorders rule out Zyban because of seizure risk?
Seizure or eating disorders.