Alpha-1 antagonist (nonselective)

Alpha-1 adrenergic receptor antagonist (nonselective)

Alpha-1 adrenergic receptor antagonist (nonselective) — mechanism peg (Ballicules) — Alpha-1 antagonist (nonselective) — mechanism card

Sympatholytic → removes “fight or flight”
If BBB-crossing: ↓ PTSD hyperarousal/nightmares
can be titrated more quickly without syncope risk
Orthostasis/first-dose syncope
↓ BP, orthostatic hypotension
Relaxes prostate/bladder neck → improves BPH
Uncommonly, retrograde ejaculation or priapism
hypertensive emergency
rescue of local extravasation of vasopressors

Drugs with this mechanism (93)

8-OH-Amoxapine Loxapine inhaled Alfuzosin Amitriptyline Amoxapine Aripiprazole Aripiprazole lauroxil LAI Aripiprazole lauroxil LAI Aripiprazole monohydrate LAI Aripiprazole monohydrate LAI Asenapine Asenapine transdermal Brexpiprazole Carvedilol Chlorpromazine Chlorpromazine injection Clomipramine Clozapine Cyclobenzaprine Cyproheptadine Dehydroaripiprazole Desipramine Desmethylclomipramine (Desmethyl-) mirtazapine Doxazosin Doxepin Doxylamine Droperidol Clozapine ODT Fluphenazine Fluphenazine decanoate LAI Fluphenazine injection Haloperidol Haloperidol decanoate LAI Haloperidol injection Hydroxynefazodone Hydroxyzine HCl Hydroxyzine IM Hydroxyzine pamoate Iloperidone Imipramine Labetalol Loxapine Lumateperone Lurasidone Maprotiline Melperone Mianserin Milsaperidone Mirtazapine Molindone Nefazodone Norclozapine Nordoxepin Norquetiapine Nortriptyline Olanzapine Olanzapine IM Olanzapine pamoate LAI Olanzapine SubQ LAI Paliperidone Paliperidone palmitate LAI Paliperidone palmitate LAI Paliperidone palmitate LAI Paliperidone palmitate LAI Perphenazine Phenoxybenzamine Phentolamine Pimozide Prazosin Prochlorperazine Prochlorperazine injection Promethazine Promethazine injection Protriptyline Quetiapine Risperidone Risperidone LAI Risperidone LAI Risperidone LAI Risperidone LAI Risperidone LAI Quetiapine XR Doxepin low-dose (insomnia) Terazosin Thioridazine Thiothixene Trazodone Trifluoperazine Trimipramine Clozapine oral suspension Ziprasidone Ziprasidone IM

Self-check

What first-dose hazard accompanies alpha-1 blockade?
Orthostasis or syncope.
Why can alpha-1 blockade improve BPH symptoms?
Relaxes the prostate and bladder neck.

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