Doxylamine
UNISOM
What it isFirst-generation H1 antagonist; insomnia, and with pyridoxine for nausea of pregnancy.
Why this oneThe pyridoxine combination is the only FDA-approved treatment for nausea and vomiting of pregnancy.
What limits itAnticholinergic burden and next-day sedation. Tolerance to the hypnotic effect develops quickly.
FDA-approved for
- insomnia (~1948)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Insomnia (OTC nighttime sleep aid) | Adults & children ≥12 y | 1 tablet QHS PRN | 1 tablet QHS | 1 tablet/day |
Renal Undefined
Hepatic Undefined
Instructions
- Take one tablet 30 minutes before going to bed.
- Do not use in children under 12 years of age.
Pregnancy Undefined
Lactation Undefined
NO BOXED WARNINGS
Principal riskAnticholinergic burden and next-day sedation
Classes and tags
Clinical profile
Mechanism of action: Doxylamine ballicule
