UGT substrate (isoform uncertain)

Interaction at a glance

• Glucuronidated, but key UGT isoform is uncertain

Magnitude / time course

• Glucuronidated, but key UGT isoform is uncertain
• UGT induction/inhibition may alter exposure

Mechanism

• Multiple UGTs may contribute
• Clinical DDI evidence outranks in-vitro assignment

Management

• Avoid false precision about a specific isoform

Self-check

• What is the preferred management of UGT substrate (isoform uncertain)?
  Avoid false precision about a specific isoform.
• Should UGT substrate (isoform uncertain) generally be combined?
  No—avoid the combination when feasible.

Drugs in this interaction (89)

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