UGT substrate (isoform uncertain)
- Glucuronidated, but key UGT isoform is uncertain
- UGT induction/inhibition may alter exposure
- Avoid false precision about a specific isoform
- Multiple UGTs may contribute
- Clinical DDI evidence outranks in-vitro assignment
Interaction at a glance
- Glucuronidated, but key UGT isoform is uncertain
Magnitude / time course
- Glucuronidated, but key UGT isoform is uncertain
- UGT induction/inhibition may alter exposure
Mechanism
- Multiple UGTs may contribute
- Clinical DDI evidence outranks in-vitro assignment
Management
- Avoid false precision about a specific isoform
Self-check
- How should an uncertain UGT isoform be described?
Avoid false isoform precision. - When assigning a UGT interaction, which evidence outranks in-vitro isoform assignment?
Clinical DDI evidence.
Drugs in this interaction (89)
![[+]-α-HTBZ ballicule — decagon mechanism diagram](/thumbs/plus_alpha_htbz.webp)
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