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Psilocin

active

What it isThe active dephosphorylated metabolite of psilocybin, a 5-HT2A agonist.

Why it mattersIt is the species that actually acts — psilocybin is a prodrug converted by intestinal phosphatase.

What it changesIts shorter half-life than the parent dosing suggests explains the sharp onset after ingestion.

FDA-approved for

NO BOXED WARNINGS

Principal riskIts shorter half-life than the parent dosing suggests explains the sharp onset after ingestion

Classes and tags

Clinical profile

Direct muscarinic antagonism0 / 4

Mechanism of action: Psilocin ballicule

Psilocin ballicule: receptor binding, kinetics and half-life diagram

Open Psilocin in the interactive console ↗