Esterase-metabolized
- Cleared substantially by ester hydrolysis
- Often rapid and relatively CYP-independent
- Plasma/tissue esterases may both contribute
- CYP DDIs may therefore be less important
- Genetic/organ effects depend on the esterase
Interaction at a glance
- Cleared substantially by ester hydrolysis
Mechanism
- Cleared substantially by ester hydrolysis
- Often rapid and relatively CYP-independent
Mechanism / modifiers
- Plasma/tissue esterases may both contribute
Mechanism / exceptions
- CYP DDIs may therefore be less important
- Genetic/organ effects depend on the esterase
Self-check
- Which pathway substantially clears drugs tagged as Esterase-metabolized?
ester hydrolysis.
Drugs in this interaction (65)
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