CYP3A4 substrate
- Cleared substantially by CYP3A4
- CYP3A4 inhibitors can raise exposure
- CYP3A4 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Largest DDI burden; gut + liver both contribute.
Interaction at a glance
- Cleared substantially by CYP3A4
Mechanism
- Cleared substantially by CYP3A4
Magnitude / time course
- CYP3A4 inhibitors can raise exposure
- CYP3A4 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Largest DDI burden; gut + liver both contribute.
Self-check
- What can happen to CYP3A4-substrate exposure when CYP3A4 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP3A4-substrate interaction?
Fraction metabolized.
Drugs in this interaction (110)
All interaction examples · Open CYP3A4 substrate in the interactive console ↗