CYP3A4 substrate
- Cleared substantially by CYP3A4
- CYP3A4 inhibitors can raise exposure
- CYP3A4 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Largest DDI burden; gut + liver both contribute.
Interaction at a glance
- Cleared substantially by CYP3A4
Mechanism
- Cleared substantially by CYP3A4
Magnitude / time course
- CYP3A4 inhibitors can raise exposure
- CYP3A4 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Largest DDI burden; gut + liver both contribute.
Self-check
- Which pathway substantially clears drugs tagged as CYP3A4 substrate?
CYP3A4.
Drugs in this interaction (110)
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