Desogestrel
in DESOGEN
What it isThird-generation progestin used in combined and progestin-only pills.
Why this oneLow androgenicity, and the progestin-only pill has a twelve-hour window rather than three.
What limits itHigher VTE risk than levonorgestrel-containing combined pills. Irregular bleeding.
FDA-approved for
- contraception with ethinyl estradiol
⚠ BOXED WARNING
- Cigarette smoking and serious cardiovascular events over age 35
Generic entry1999
Classes and tags
Clinical profile
Legacy pregnancy categoryX
Defining liabilityVenous thromboembolism and hormone-related adverse effects; estrogen also lowers lamotrigine exposure.
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Self-check
- What dosing window does the desogestrel-only pill have?
Twelve hours rather than three. - How does combined-pill VTE risk compare with levonorgestrel combinations?
Higher.