Norepinephrine reuptake inhibitor
- ↑ extracellular norepinephrine
- Inhibits norepinephrine transporter (NET)
- ↑ prefrontal dopamine (NET clears dopamine there)
- Improves attention
- Antidepressant effect
- Can raise heart rate and blood pressure
- Non-stimulant ADHD meds classified as NETs:
- atomoxetine (STRATTERA)
- viloxazine (QELBREE)
- TCAs that are functional NRIs with off-target effects:
- nortriptyline (PAMELOR)
- desipramine (NORPRAMIN)
- maprotiline (LUDIOMIL)
- Antipsychotic with significant NRI effect:
- quetiapine (SEROQUEL, active metabolite)
Drugs with this mechanism (62)
8-OH-Amoxapine
Methylphenidate XR (Adhansia)
Amitriptyline
Amoxapine
Bupropion hydrobromide ER
Methylphenidate XR (Aptensio)
Atomoxetine
Bupropion
Centanafadine
Clomipramine
Cocaine
Methylphenidate ER (OROS)
Methylphenidate XR-ODT
Methylphenidate patch
Desipramine
Desmethylclomipramine
Desmethylsertraline
Desvenlafaxine
Dexmethylphenidate
Doxepin
Duloxetine
Venlafaxine XR
Fluoxetine
Dexmethylphenidate XR
Bupropion XL 450 mg
Hydroxybupropion
Imipramine
Methylphenidate ER evening-dosed
Levomilnacipran
Maprotiline
Methylenedioxypyrovalerone
Methylphenidate CD
Methylphenidate
Methylphenidate chewable
Methylphenidate oral solution
Methylphenidate SR
Milnacipran
Netarsudil
Nordoxepin
Norfluoxetine
Norquetiapine
Nortriptyline
Paroxetine
Paroxetine CR
Protriptyline
Methylphenidate ER chewable
Methylphenidate ER suspension
Reboxetine
Methylphenidate ER (Relexxii)
Methylphenidate LA
Sertraline
Doxepin low-dose (insomnia)
Tapentadol
Tramadol
Tramadol ER
Venlafaxine
Viloxazine
Bupropion SR
Bupropion XL
Ziprasidone
Ziprasidone IM
Bupropion SR (smoking cessation)
Self-check
- Why can NET inhibition increase prefrontal dopamine?
NET clears dopamine there. - Which cardiovascular measures can NET inhibition raise?
Heart rate and blood pressure.
All mechanisms · Open NET inhibitor in the interactive console ↗