Nephrotoxicity

Interaction at a glance

• Can injure kidney or reduce renal function

Mechanism

• Mechanism may be hemodynamic, tubular or crystal

Magnitude / time course

• Rising creatinine may increase exposure further

Clinical consequence

• Dehydration + other nephrotoxins magnify risk

Who is at greatest risk

• Can injure kidney or reduce renal function
• Monitor renal function when risk is meaningful

Self-check

• What should be monitored with Nephrotoxicity?
  Renal function when risk is meaningful.
• Key clinical effect of Nephrotoxicity?
  Dehydration + other nephrotoxins magnify risk.

Drugs in this interaction (51)

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