Half-life (very long)
- Elimination half-life is unusually prolonged
- Accumulation and washout can take many days
- Adverse effects/DDIs may persist after stopping
- Time to steady state is correspondingly long
- Loading or slow titration may be clinically relevant
Interaction at a glance
- Elimination half-life is unusually prolonged
Timing / washout
- Accumulation and washout can take many days
- Adverse effects/DDIs may persist after stopping
Mechanism
- Time to steady state is correspondingly long
- Loading or slow titration may be clinically relevant
Magnitude / time course
- Elimination half-life is unusually prolonged
Self-check
- What major clinical effect is associated with Half-life (very long)?
Adverse effects/DDIs may persist after stopping.
Drugs in this interaction (80)
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