5-HT2C antagonist

Name: 5-HT2C antagonist
Creator: Jason Cafer, MD

5-HT2C serotonin receptor antagonist

Removes serotonin’s appetite-suppressing brake
Contributor to weight gain when in context of D2 blockade (Kirk et al, 2009)— “I’d like ‘2C’ my feet”
Possible amplification of H1-antagonist-induced weight gain
↑ DA and NE activity in frontal cortex
➔ “activating” antidepressant effect

Drugs with this mechanism (50)