Mu-opioid agonist

Mu-opioid agonist (1/3)

• Strong analgesia
• Euphoria
• High abuse liability

Mu-opioid agonist (2/3)

• Physical dependence
• Sedation
• Constipation
• Respiratory depression
• Cough suppression
• Miosis (pupillary constriction)
• Nausea/emesis (especially initially)
• Hyperalgesia with chronic use

Mu-opioid agonist (3/3)

• Suppression of hypothalamic-pituitary-adrenal (HPA) axis
• ➔ decreased CRH release
• ➔ decreased ACTH secretion
• ➔ blunted cortisol response

Drugs with this mechanism (36)

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