Morphine-6-glucuronide
from morphine
What it isMorphine-6-glucuronide, the active analgesic metabolite of morphine.
Why it mattersMore potent at the mu receptor than morphine itself and contributes meaningfully to analgesia during chronic dosing.
What it changesIt accumulates in renal failure, where delayed sedation and respiratory depression from M6G can outlast the parent drug.
NO BOXED WARNINGS
Classes and tags
Open Morphine-6-glucuronide in the interactive console ↗
Self-check
- How does M6G’s mu-receptor potency compare with morphine’s?
Greater potency. - Why can M6G toxicity outlast morphine in renal failure?
It accumulates, causing delayed sedation and respiratory depression.