COX-2 inhibitor
Cyclooxygenase-2 inhibitor
- The inducible inflammatory isoform
- ↓ inflammatory prostaglandins → analgesic/anti-inflammatory effect
- Less GI toxicity than COX-1 inhibition
- Spares platelet COX-1 unless paired with COX-1 inhibition
- Shifts the prostacyclin/thromboxane balance toward thrombosis
Drugs with this mechanism (29)
Aspirin
Bromfenac
Diclofenac oral solution
Celecoxib
Diclofenac
Diclofenac topical gel
Diflunisal
Etodolac
Etoricoxib
Fenoprofen
Diclofenac topical patch
Flurbiprofen
Ibuprofen
Imrecoxib
Indomethacin
Ketoprofen
Ketorolac
Ketorolac injection
Meclofenamate
Mefenamic acid
Meloxicam
Naproxen
Oxaprozin
Piroxicam
Salicylate
Salsalate
6-MNA
Sulindac sulfide
Tolmetin
Self-check
- How does GI toxicity compare with COX-1 inhibition?
Less GI toxicity. - In which direction does COX-2 inhibition shift the prostacyclin/thromboxane balance?
Toward thrombosis.
All mechanisms · Open COX-2 inhibitor in the interactive console ↗