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Mechanisms
› COX-1 inhibitor
COX-1 inhibitor
Cyclooxygenase-1 inhibitor
Reduces protective gastric prostaglandins
➔ GI ulceration and bleeding risk
Drugs with this mechanism (29)
Acetaminophen
Aspirin
Bromfenac
Diclofenac oral solution
Celecoxib
Diclofenac
Diclofenac topical gel
Diflunisal
Etodolac
Fenoprofen
Diclofenac topical patch
Flurbiprofen
Ibuprofen
Icosapent ethyl
Indomethacin
Ketoprofen
Ketorolac
Meclofenamate
Mefenamic acid
Meloxicam
Naproxen
Omega-3 fatty acids
Oxaprozin
Piroxicam
Salicylate
Salsalate
6-MNA
Sulindac sulfide
Tolmetin
All mechanisms
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