COX-1 inhibitor
Cyclooxygenase-1 inhibitor
- The constitutive housekeeping isoform
- ↓ protective gastric prostaglandins → ulcer/bleeding risk
- ↓ platelet thromboxane A2 → antiplatelet effect
Drugs with this mechanism (27)
Aspirin
Bromfenac
Diclofenac oral solution
Celecoxib
Diclofenac
Diclofenac topical gel
Diflunisal
Etodolac
Fenoprofen
Diclofenac topical patch
Flurbiprofen
Ibuprofen
Indomethacin
Ketoprofen
Ketorolac
Ketorolac injection
Meclofenamate
Mefenamic acid
Meloxicam
Naproxen
Oxaprozin
Piroxicam
Salicylate
Salsalate
6-MNA
Sulindac sulfide
Tolmetin
Self-check
- Why does COX-1 inhibition increase ulcer risk?
Reduces protective gastric prostaglandins. - Which platelet mediator falls with COX-1 inhibition?
Thromboxane A2.
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