Protein bound (highly)
- Large fraction circulates protein-bound
- Free fraction is pharmacologically available
- Albumin/AAG changes can alter total levels
- High binding can reduce dialyzability
- Binding alone rarely predicts all DDIs
Interaction at a glance
- Large fraction circulates protein-bound
Mechanism
- Large fraction circulates protein-bound
- Free fraction is pharmacologically available
- Binding alone rarely predicts all DDIs
Mechanism / modifiers
- Albumin/AAG changes can alter total levels
Management
- High binding can reduce dialyzability
Self-check
- Which drug fraction is pharmacologically available?
The free fraction. - How can high protein binding affect dialysis removal?
Reduce it.
Drugs in this interaction (47)
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