CYP2D6 substrate
- Cleared substantially by CYP2D6
- CYP2D6 inhibitors can raise exposure
- CYP2D6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype and inhibitors can cause phenoconversion.
Interaction at a glance
- Cleared substantially by CYP2D6
Magnitude / time course
- Cleared substantially by CYP2D6
- CYP2D6 inhibitors can raise exposure
Exposure modifiers
- CYP2D6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Genotype and inhibitors can cause phenoconversion.
Self-check
- Which pathway substantially clears drugs tagged as CYP2D6 substrate?
CYP2D6.
Drugs in this interaction (44)
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