CYP2D6 substrate
- Cleared substantially by CYP2D6
- CYP2D6 inhibitors can raise exposure
- CYP2D6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Genotype and inhibitors can cause phenoconversion.
Interaction at a glance
- Cleared substantially by CYP2D6
Magnitude / time course
- Cleared substantially by CYP2D6
- CYP2D6 inhibitors can raise exposure
Exposure modifiers
- CYP2D6 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
Mechanism
- Genotype and inhibitors can cause phenoconversion.
Self-check
- What can happen to CYP2D6-substrate exposure when CYP2D6 is inhibited?
Exposure can rise. - What determines the clinical impact of a CYP2D6-substrate interaction?
Fraction metabolized.
Drugs in this interaction (44)
All interaction examples · Open CYP2D6 substrate in the interactive console ↗