Antiarrhythmics (Vaughan-Williams)
- Mechanism-based antiarrhythmic framework
- I Na+; II beta; III K+; IV Ca2+
- Many drugs have mixed-class actions
- Choice depends on rhythm + heart disease
- Proarrhythmia is a class-wide concern
- ECG intervals often reveal mechanism/toxicity
Class at a glance
- Mechanism-based antiarrhythmic framework
- I Na+; II beta; III K+; IV Ca2+
Practical pearls
- Many drugs have mixed-class actions
Members / distinctions
- Choice depends on rhythm + heart disease
- Proarrhythmia is a class-wide concern
Safety / monitoring
- ECG intervals often reveal mechanism/toxicity
Self-check
- What guides antiarrhythmic choice?
Rhythm and heart disease. - Which channels define Vaughan-Williams class I?
Na+ channels.
Drugs in this class (23)
Antiarrhythmics (Vaughan-Williams) prescription history
Animated chart of estimated U.S. prescriptions per year, Antiarrhythmics (class I/III) (1930–2026).
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