Antiarrhythmics (Vaughan-Williams)

Class at a glance

• Mechanism-based antiarrhythmic framework
• I Na+; II beta; III K+; IV Ca2+

Practical pearls

• Many drugs have mixed-class actions

Members / distinctions

• Choice depends on rhythm + heart disease
• Proarrhythmia is a class-wide concern

Safety / monitoring

• ECG intervals often reveal mechanism/toxicity

Self-check

• What is the key clinical organizing principle for Antiarrhythmics (Vaughan-Williams)?
  Mechanism-based antiarrhythmic framework.

Drugs in this class (23)

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