Dopamine reuptake inhibitor

• ↑ extracellular dopamine
• Wakefulness, focus and, at high DAT occupancy, reinforcement
• Rapid onset + high occupancy → greater abuse potential
• No clinically available selective DRIs
• they are NRIs also DRI DRI DAT

Drugs with this mechanism (32)

Self-check

• What combination increases DAT-blocker abuse potential?
  Rapid onset plus high occupancy.
• What happens to extracellular dopamine with DAT blockade?
  It increases.

All mechanisms · Open DAT inhibitor in the interactive console ↗