Opioid + gabapentinoid

Interaction at a glance

• Use lowest effective doses; titrate slowly
• Watch somnolence + shallow breathing

Monitoring

• Watch somnolence + shallow breathing

Clinical consequence

• Both can suppress CNS/respiration
• Gabapentinoids amplify opioid sedation
• Risk ↑ with age, COPD, renal impairment

Management

• Use lowest effective doses; titrate slowly

Self-check

• What is the main clinical risk of Opioid + gabapentinoid?
  Gabapentinoids amplify opioid sedation.
• What major clinical effect is associated with Opioid + gabapentinoid?
  Risk ↑ with age, COPD, renal impairment.

Drugs in this interaction (35)

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