Opioid + gabapentinoid

Interaction at a glance

• Use lowest effective doses; titrate slowly
• Watch somnolence + shallow breathing

Monitoring

• Watch somnolence + shallow breathing

Clinical consequence

• Both can suppress CNS/respiration
• Gabapentinoids amplify opioid sedation
• Risk ↑ with age, COPD, renal impairment

Management

• Use lowest effective doses; titrate slowly

Self-check

• Key risk with Opioid + gabapentinoid?
  Gabapentinoids amplify opioid sedation.
• What increases opioid–gabapentinoid risk?
  Age, COPD and renal impairment.

Drugs in this interaction (35)

All interaction examples · Open Opioid + gabapentinoid in the interactive console ↗