DOAC + NSAID/antiplatelet — bleeding

Interaction at a glance

• Pharmacodynamic bleeding interaction
• DOAC impairs coagulation
• NSAID/antiplatelet impairs hemostasis
• Avoid chronic combo unless indicated

Clinical consequence

• Pharmacodynamic bleeding interaction
• DOAC impairs coagulation
• NSAID/antiplatelet impairs hemostasis

Who is at greatest risk

• GI bleeding risk especially increases

Management

• Avoid chronic combo unless indicated
• Use gastroprotection when appropriate

Self-check

• What is the main clinical risk of DOAC + NSAID/antiplatelet?
  Pharmacodynamic bleeding interaction.
• What is the preferred management of DOAC + NSAID/antiplatelet?
  Avoid chronic combo unless indicated.

Drugs in this interaction (32)

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