Antiemetics

Class at a glance

• Multiple classes; match drug to emetic pathway

Members / distinctions

• NK1: highly emetogenic chemotherapy

Pharmacology

• D2 blockers: broad rescue + gastroparesis

Clinical role

• 5-HT3: chemo/post-op nausea
• H1/M1 drugs: motion/vestibular nausea
• Olanzapine is powerful for CINV

Safety / monitoring

• QT, EPS, sedation differ by mechanism

Self-check

• Which antiemetic mechanism is common for chemotherapy/post-op nausea?
  5-HT3 blockade.
• Which antiemetic mechanisms help motion/vestibular nausea?
  H1/M1 blockade.

Drugs in this class (18)

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