Sympathomimetic

Interaction at a glance

• Increases adrenergic signaling

Mechanism

• Increases adrenergic signaling
• HR, BP, alertness + vasoconstriction may rise

Mechanism / modifiers

• MAOI combinations can be especially dangerous
• Mechanism may be direct agonism or NE release

Clinical consequence

• Stacking sympathomimetics magnifies toxicity

Self-check

• Key risk with Sympathomimetic?
  Stacking sympathomimetics magnifies toxicity.
• Which combinations can be especially dangerous with sympathomimetics?
  MAOI combinations.

Drugs in this interaction (35)

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