Protein binding (albumin)
- Drug binds primarily to albumin
- Only unbound drug crosses membranes/gets filtered
- Low albumin can raise free fraction
- Total level may mislead when binding changes
- Displacement alone rarely causes sustained toxicity
Interaction at a glance
- Drug binds primarily to albumin
Mechanism
- Drug binds primarily to albumin
- Only unbound drug crosses membranes/gets filtered
- Low albumin can raise free fraction
Mechanism / modifiers
- Total level may mislead when binding changes
Clinical consequence
- Displacement alone rarely causes sustained toxicity
Self-check
- Why can total drug levels mislead when albumin binding changes?
The free fraction may change.
- Does protein-binding displacement alone usually cause sustained toxicity?
No.
Drugs in this interaction (23)
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