CYP2C9 substrate
- Cleared substantially by CYP2C9
- CYP2C9 inhibitors can raise exposure
- CYP2C9 inducers can lower exposure
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Warfarin/phenytoin/NSAIDs are classic substrates.
Interaction at a glance
- Cleared substantially by CYP2C9
Mechanism
- Cleared substantially by CYP2C9
Magnitude / time course
- CYP2C9 inhibitors can raise exposure
- CYP2C9 inducers can lower exposure
Mechanism / modifiers
- Clinical impact depends on fraction metabolized
- Sensitive substrates show the largest DDIs
- Warfarin/phenytoin/NSAIDs are classic substrates.
Self-check
- Which pathway substantially clears drugs tagged as CYP2C9 substrate?
CYP2C9.
Drugs in this interaction (15)
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