Targeted antineoplastics
- Attack defined tumor pathways/biomarkers
- Includes kinase, hormone + DNA-repair targets
- Biomarker testing often determines eligibility
- Resistance mutations can emerge
- Toxicity can be pathway-specific, not “milder”
- Oral agents often have major DDIs
Class at a glance
- Attack defined tumor pathways/biomarkers
Practical pearls
- Includes kinase, hormone + DNA-repair targets
Members / distinctions
- Biomarker testing often determines eligibility
- Resistance mutations can emerge
- Oral agents often have major DDIs
Safety / monitoring
- Toxicity can be pathway-specific, not “milder”
Self-check
- Which groups are included in Targeted antineoplastics?
Kinase, hormone + DNA-repair targets. - What often determines eligibility for targeted antineoplastics?
Biomarker testing.
Drugs in this class (36)
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