Prodrugs

Class at a glance

• Administered compound needs conversion to active drug

Practical pearls

• Activation may be enzymatic or chemical

Other practical pearls

• Genetics/DDIs can alter activation for some

Members / distinctions

• Parent exposure may not equal active exposure
• Important for PK and interaction reasoning

Self-check

• Does parent-drug exposure necessarily equal active-drug exposure?
  No.
• What can alter activation of some prodrugs?
  Genetics and DDIs.

Drugs in this class (38)

All drug classes · Open Prodrugs in the interactive console ↗