Psilocybin
prodrug
Pronunciation: sye-loe-SYE-bin
What it isProdrug of psilocin, a 5-HT2A agonist; investigational for depression.
Why this oneA supervised session produces effects lasting weeks to months, unlike daily antidepressants.
What limits itAnxiety and blood pressure rise during the session, requiring monitoring. Not approved; contraindicated in psychosis risk.
Pearls
- Suicidality and self-harm reported after dosing; arrange follow-up.
- Lithium co-use linked to seizures.
Used for
- treatment-resistant depression (phase 3; FDA breakthrough designation)
NO BOXED WARNINGS
Principal riskAnxiety and blood pressure rise during the session, requiring monitoring
Classes and tags
Clinical profile
Active metabolites
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Self-check
- Psilocybin: Which active compound is formed from it?
Psilocin. - Psilocybin: Which psychiatric risk contraindicates it in this source?
Psychosis risk.