Psilocybin
prodrug
What it isProdrug of psilocin, a 5-HT2A agonist; investigational for depression.
Why this oneA supervised session produces effects lasting weeks to months, unlike daily antidepressants.
What limits itAnxiety and blood pressure rise during the session, requiring monitoring. Not approved; contraindicated in psychosis risk.
FDA-approved for
- treatment-resistant depression (breakthrough designation; investigational)
Off-label
- treatment-resistant depression (phase 3; FDA breakthrough designation)
NO BOXED WARNINGS
Principal riskAnxiety and blood pressure rise during the session, requiring monitoring
Classes and tags
Clinical profile
Active metabolites
Mechanism of action: Psilocybin ballicule
