MAOI + potentially fatal combinations (Gillman)

Interaction at a glance

• MAO-A inhibition + strong serotonin rise
• Never combine; allow adequate washout

Timing / washout

• Never combine; allow adequate washout

Mechanism

• Centanafadine belongs on this side

Clinical consequence

• MAO-A inhibition + strong serotonin rise
• Can cause severe/fatal serotonin toxicity
• SSRIs/SNRIs/clomipramine
• tramadol/meperidine/dextromethorphan

Self-check

• What is the management of potentially fatal MAOI combinations?
  Never combine; allow adequate washout.
• What toxicity can potentially fatal MAOI combinations cause?
  Severe/fatal serotonin toxicity.

Drugs in this interaction (34)

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